Resources

Life-span shortens even with beats per minute in the 80s or 90s, but "what I'm showing is by exercising, you reduce the mortality, and that's even more important than heart rate."  

No control group, but also no deaths and only four CV events in 1.7 years in 106 patients on the PCSK9 inhibitor. "Which is remarkable" in HoFH, says a researcher; still, all urge caution interpreting the results.  

At first presentation of a newly pregnant woman with chronic hypertension, arrange prompt referral to an obstetrician, preferably one specialising in hypertension  

In the last of a series on the implications for health of the UK leaving the European Union, Anne Gulland examines the likely effects on freedom of movement  

At first presentation of a newly pregnant woman with chronic hypertension, arrange prompt referral to an obstetrician, preferably one specialising in hypertension  

Autosomal dominant polycystic kidney disease (ADPKD) was previously known as “adult PKD” because most cases come to medical attention during adulthood. However, clinically important morbidity such as hypertension and cardiovascular disease occurs much earlier. Screening children could detect those affected, and randomised controlled trials show that early intervention reduces disease progression. Despite this, very few children from families with the condition are currently assessed in the United Kingdom.  

How do COPD patients fare in the long-term after undergoing coronary artery bypass grafting?  

How do these two methods for measuring oxygen consumption compare? Is one superior to the other?  

We face barriers in the assessment, treatment and evaluation of pain in elders. Read how to overcome these barriers here.  

If your lab isn't using MicrobeNet, you are missing out on faster pathogen detection than is possible by conventional means.  

How does activation of inflammatory pathways contribute to progressive adverse LV remodeling after acute MI?  

Might plasma levels of the gut-derived metabolite trimethylamine N-oxide have utility as a prognostic marker in acute heart failure?  

Should renal replacement therapy be initiated early to improve outcomes?  

Apply your knowledge to 2 clinical case challenges in relapsed/refractory Hodgkin lymphoma.  

Most patients prefer their dermatologists to wear a white coat, regardless of the clinic setting, a new survey suggests.  

The FDA has long warned about the risk for serious bleeding with OTC aspirin-containing antacids, but it still receives reports about this adverse event.  

Screening of urine bag specimens for urinary tract infections (UTIs) can obviate catheterization in many very young febrile emergency department (ED) patients, according to Pennsylvania-based researchers.  

If you want to win an exclusive* Don’t Forget The Bubbles t-shirt then take a #SMACCselfie displaying your DFTB badges, stickers or tattoos (yes, we have those too!) and tag #DFTB.  Each day one lucky winner, drawn at random, will win a t-shirt.  

A 2 week old baby, Isabelle, is rushed into the emergency department by her frantic parents. She is tachycardic to 220bpm, febrile to 39.5°C, with a widespread, blanching red rash. She is screaming and looks very unwell. She is rushed into a resus bay and the septic workup begins…  

In Part 1, Chris Nickson’s Nuts (and bolts of EBM) touched on the PICO question. When we have a clinical question, we look to see if it has been answered, focusing on specific patients, interventions, comparisons and outcomes.