I'm not sure why I like to quote lines from films on this blog. I mean, I really haven't seen enough of them to make myself out to be some sort of hotshot film geek. I'm hoping this is the last (probably inappropriate) quote I use for a while, so here goes... 'Give me a word, any word, and I show you that the root of that word is Greek.' Courtesy of Gus Portokalos, the funniest character in the My Big Fat Greek Wedding. Sometimes I feel like medics tend to do that, we have a habit of making absolutely any conversation about Medicine. It seems to give us a bit of a bad rep, but surely it's understandable? I mean, it's what we do. It's what we've 'always wanted to do' i.e. since leaving the womb*. It's what we're always going to do. Right?
Even so, it's surely human nature to relate everyday conversation to something you think that you know a lot about. Let's take a look at real-life example, cue the Blue Peter quip 'here's one I made earlier':
I know nothing about football. Well, I know a bit more than some and a lot less than your average football fan so I guess I know VERY little about football. I do, however, know a thing or two about Hillsborough Stadium in Sheffield. Why, you ask? Well, the Hillsborough Disaster in 1985 saw the deaths of 96 Liverpool fans during an FA cup semi-final. A pivotal case emerged from this disaster which affected medical decision-making at the end of life, that of Anthony Bland. Bland was left brain damaged and in a 'persistent vegetative state' (a disorder of consciousness) after the disaster. In 1993, he finally won his battle to have the treatment that was keeping him alive withdrawn. This was a landmark case in both medical ethics and law. Don't say you heard it hear first, look it up: it's relevant.
It would be dishonest to say, 'Give me a word, any word, and I'll show you that it's somehow linked to Medicine. But just ask me what I know about football, just once and I might just surprise you.
*After writing this entry, I realised that it might be unfair to presume that there isn't at least one person who knew that they wanted to be a doctor just seconds after taking their first gasp of air and crying their eyes out in the midwife's arms. My sincere apologies if this applies to you.
(To have a look at more of my entries, visit: http://contemplationsofamedic.blogspot.co.uk/)
Rates of five serious complications related to diabetes—myocardial infarction, stroke, end stage kidney failure, lower limb amputation, and death from hyperglycemia — have all decreased among adults with diabetes in the US over the past two decades, according to a new study by the US Centers for Disease Control and Prevention (CDC).1
So you're sitting in a bus when you see a baby smile sunnily and gurgle at his mother. Your automatic response? You smile too. You're jogging in the park, when you see a guy trip over his shoelaces and fall while running. Your knee jerk reaction? You wince. Even though you're completely fine and unscathed yourself. Or, to give a more dramatic example; you're watching Titanic for the umpteenth time and as you witness Jack and Rose's final moments together, you automatically reach for a tissue and wipe your tears in whole hearted sympathy ( and maybe blow your nose loudly, if you're an unattractive crier like yours truly).
And here the question arises- why? Why do we experience the above mentioned responses to situations that have nothing to do with us directly? As mere passive observers, what makes us respond at gut level to someone else's happiness or pain, delight or excitement, disgust or fear? In other words, where is this instinctive response to other people's feelings and actions that we call empathy coming from?
Science believes it may have discovered the answer- mirror neurons.
In the early 1990s, a group of scientists (I won't bore you with the details of who, when and where) were performing experiments on a bunch of macaque monkeys, using electrodes attached to their brains. Quite by accident, it was discovered that when the monkey saw a scientist holding up a peanut, it fired off the same motor neurons in its brain that would fire when the monkey held up a peanut itself. And that wasn't all. Interestingly, they also found that these motor neurons were very specific in their actions. A mirror neuron that fired when the monkey grasped a peanut would also fire only when the experimenter grasped a peanut, while a neuron that fired when the monkey put a peanut in its mouth would also fire only when the experimenter put a peanut in his own mouth. These motor neurons came to be dubbed as 'mirror neurons'.
It was a small leap from monkeys to humans. And with the discovery of a similar, if not identical mirror neuron system in humans, the studies, hypotheses and theories continue to build. The strange thing is that mirror neurons seem specially designed to respond to actions with clear goals- whether these actions reach us through sight, sound, smell etc, it doesn't matter. A quick example- the same mirror neurons will fire when we hop on one leg, see someone hopping, hear someone hopping or hear or read the word 'hop'. But they will NOT respond to meaningless gestures, random or pointless sounds etc. Instead they may well be understanding the intentions behind the related action. This has led to a very important hypothesis- the 'action understanding' ability of mirror neurons.
Before the discovery of mirror neurons, scientists believed our ability to understand each other, to interpret and respond to another's feeling or actions was the result of a logical thought process and deduction. However, if this 'action understanding' hypothesis is proved right, then it would mean that we respond to each other by feeling, instead of thinking. For instance, if someone smiles at you, it automatically fires up your mirror neurons for smiling. They 'understand the action' and induce the same sensation within you that is associated with smiling. You don't have to think about what the other person intends by this gesture. Your smile flows thoughtlessly and effortlessly in return.
Which brings us to yet another important curve- if mirror neurons are helping us to decode facial expressions and actions, then it stands to reason that those gifted people who are better at such complex social interpretations must be having a more active mirror neuron system.(Imagine your mom's strained smile coupled with the glint in her eye after you've just thrown a temper tantrum in front of a roomful of people...it promises dire retribution my friends. Trust me.)
Then does this mean that people suffering from disorders such as autism (where social interactions are difficult) have a dysfunctional or less than perfect mirror neuron system in some way?
Some scientists believe it to be so. They call it the 'broken mirror hypothesis', where they claim that malfunctioning mirror neurons may be responsible for an autistic individual's inability to understand the intention behind other people's gestures or expressions. Such people may be able to correctly identify an emotion on someone's face, but they wouldn't understand it's significance. From observing other people, they don't know what it feels like to be sad, angry, surprised or scared.
However, the jury is still out on this one folks. The broken mirror hypothesis has been questioned by others who are still skeptical about the very existence of these wonder neurons, or just how it is that these neurons alone suffered such a developmental hit when the rest of the autistic brain is working just dandy? Other scientists argue that while mirror neurons may help your brain to understand a concept, they may not necessarily ENCODE that concept. For instance, babies understand the meaning behind many actions without having the motor ability to perform them. If this is true, then an autistic person's mirror neurons are perfectly fine...they were just never responsible for his lack of empathy in the first place.
Slightly confused? Curious to find out more about these wunderkinds of the human brain? Join the club. Whether you're an passionate believer in these little fellas with their seemingly magical properties or still skeptical, let me add to your growing interest with one parting shot- since imitation appears to be the primary function of mirror neurons, they might well be partly responsible for our cultural evolution! How, you ask? Well, since culture is passed down from one generation to another through sharing, observation followed by imitation, these neurons are at the forefront of our lifelong learning from those around us. Research has found that mirror neurons kick in at birth, with infants just a few minutes old sticking their tongues out at adults doing the same thing.
So do these mirror neurons embody our humanity? Are they responsible for our ability to put ourselves in another person's shoes, to empathize and communicate our fellow human beings? That has yet to be determined. But after decades of research, one thing is for sure-these strange cells haven't yet ceased to amaze and we definitely haven't seen the last of them. To quote Alice in Wonderland, the tale keeps getting "curiouser and curiouser"!