Despite major advances in understanding the immunopathology of type 1 diabetes, the promise of successful immune-based therapies has so far been unfulfilled. This two-paper Series from The Lancet Diabetes & Endocrinology covers the current challenges faced in the development of immune-based therapies for type 1 diabetes and approaches to overcome them in the future. In the first Series paper, Mark Atkinson and colleagues discuss the challenge of modulating β-cell autoimmunity in type 1 diabetes, highlighting how gaps in understanding of disease pathogenesis and issues with study design have hampered advances in translating initially promising preclinical approaches into clinical therapies, and recommending several approaches to advance progress in this area. In the second Series paper, Bart Roep and colleagues focus on antigen-specific immunotherapy approaches, highlighting recent research advances and the opportunities and challenges of translating research findings into clinical strategies that prevent progressive loss of β-cell function and survival in patients.  

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Type 2 diabetes is a complex systems disease, caused by interactions between lifestyle and genes. It is an illusion to believe that it can be cured by medication. Lifestyle change should always be at the heart of treatment.  

The moment a 39-year-old woman hears for the first time in her life, thanks to cochlear implants, is captured on video.  

New study suggests that risk for lung cancer is highly persistent after quitting smoking, among former heavy smokers.  

The NHS is facing the biggest challenge in its history because of the squeeze on its budget, says its new boss on his first day in the job.  

Radiopaedia.org, the online collaborative radiology resource.  

Evidence-based recommendations on the diagnosis and management of hypertension (high blood pressure) in adults  

Evidence-based statements to deliver quality improvements in the health and wellbeing of all employees, including their mental health  

A third of GPs in the United Kingdom are considering retiring from general practice in the next five years, a survey of the profession has found.  

Evidence-based recommendations on the diagnosis and management of hypertension (high blood pressure) in pregnancy  

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Diabetic retinopathy - ruboxistaurin [ID382]  

For many complex reasons tuberculosis has the unenviable position of being the leading infectious cause of death, but a notable reason is that much about it is still unknown, particularly in relation to its transmission.  

 

View latest cardiology news, CME, clinical trial info, treatment guidelines, journal articles & more.  

CathWorks announced that its FFRangio System received FDA 510(k) clearance. The FFRangio system demonstrated accuracy versus the invasive FFR wire...  

A step by step guide to performing venepuncture in an OSCE setting, with an included video demonstration.