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HOUJC1 2009 | Case 8

ResearchToPractice.com/HOUJC109 – Case 8: 65yo man presenting w/pneumococcal pneumonia & bacteremia, found to have CLL & was treated w/pentostatin/cyclophosphamide/rituximab. Interviews conducted by Neil Love, MD. Produced by Research To Practice.  
Dr Neil Love
over 10 years ago
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Critical Care

Selective digestive decontamination (SDD) and selective oropharyngeal decontamination (SOD) have been associated with reduced mortality and lower ICU-acquired bacteremia and ventilator-associated pneumonia rates in areas with low levels of antibiotic resistance. However, the effect of selective decontamination (SDD/SOD) in areas where multidrug-resistant Gram-negative bacteria are endemic is less clear. It will be important to determine whether SDD/SOD improves patient outcome in such settings and how these measures affect the epidemiology of multidrug-resistant Gram-negative bacteria. Here we review the current evidence on the effects of SDD/SOD on antibiotic resistance development in individual ICU patients as well as the effect on ICU ecology, the latter including both ICU-level antibiotic resistance and antibiotic resistance development during long-term use of SDD/SOD.  
ccforum.com
over 5 years ago