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HOUJC1 2009 | Case 8 – Case 8: 65yo man presenting w/pneumococcal pneumonia & bacteremia, found to have CLL & was treated w/pentostatin/cyclophosphamide/rituximab. Interviews conducted by Neil Love, MD. Produced by Research To Practice.  
Dr Neil Love
over 10 years ago

Critical Care

Selective digestive decontamination (SDD) and selective oropharyngeal decontamination (SOD) have been associated with reduced mortality and lower ICU-acquired bacteremia and ventilator-associated pneumonia rates in areas with low levels of antibiotic resistance. However, the effect of selective decontamination (SDD/SOD) in areas where multidrug-resistant Gram-negative bacteria are endemic is less clear. It will be important to determine whether SDD/SOD improves patient outcome in such settings and how these measures affect the epidemiology of multidrug-resistant Gram-negative bacteria. Here we review the current evidence on the effects of SDD/SOD on antibiotic resistance development in individual ICU patients as well as the effect on ICU ecology, the latter including both ICU-level antibiotic resistance and antibiotic resistance development during long-term use of SDD/SOD.
over 5 years ago