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Critical Care

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​4.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://​creativecommons.​org/​publicdomain/​zero/​1.​0/​) applies to the data made available in this article, unless otherwise stated.  
ccforum.com
almost 6 years ago
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Critical Care

Tissue reperfusion following hemorrhagic shock may paradoxically cause tissue injury and organ dysfunction by mitochondrial free radical expression. Both nitrite and carbon monoxide (CO) may protect from this reperfusion injury by limiting mitochondrial free radial production. We explored the effects of very small doses of inhaled nitrite and CO on tissue injury in a porcine model of hemorrhagic shock.  
ccforum.com
almost 6 years ago
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24

Critical Care

Neuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, traumatic and nontraumatic cerebral lesions. However, use of these potential interventions in human randomized controlled studies has generally given disappointing results. In this paper, we summarize the current status in terms of neuroprotective strategies, both in the immediate and later stages of acute brain injury in adults. We also review potential new strategies and highlight areas for future research.  
ccforum.com
almost 6 years ago
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8

Critical Care

Postoperative acute kidney injury (AKI) is a frequently observed phenomenon after cardiac surgery with cardio-pulmonary bypass (CPB); this severe complication is associated with adverse patient outcomes. There are multiple mechanisms involved in AKI during cardiac surgery, including CPB-dependent hemolysis. An IV infusion of sodium bicarbonate, which leads to urine alkalization, may play a role in preventing AKI. Recently, several trials have investigated the effect of sodium bicarbonate and reported controversial results. The purpose of this investigation was to investigate the following question. Under what circumstances can sodium bicarbonate prevent postoperative AKI?  
ccforum.com
almost 6 years ago
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8

Critical Care

Children admitted to a pediatric intensive care unit (ICU) are at high risk of developing acute kidney injury (AKI). Although serum creatinine (SCr) levels are used in clinical practice, they are insensitive for early diagnosis of AKI. Urinary neutrophil gelatinase-associated lipocalin (uNGAL) and kidney injury molecule-1 (KIM-1) are novel AKI biomarkers whose performance in pediatric ICU patients is largely unknown. In this study, we aimed to characterize uNGAL and KIM-1 patterns in children following ICU admission and to assess their properties in relation to identifying children at risk for AKI development.  
ccforum.com
almost 6 years ago
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31

ECMO - Avalon Cannula - Intensive Care Network

Intensivist Dr Roger Pye demonstrates the Avalon Cannula for ECMO. Presented at SMACCGold 2014.  
intensivecarenetwork.com
almost 6 years ago
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15

Keeping it real! Critical Care Collaborative 2015 - Melbourne - Intensive Care Network

Calling all Victorian doctors, nurses, paramedics, physiotherapists, dieticians, pharmacists and beyond! You are invited to the 2015 Critical Care Collaborative (CCC), Victoria's only critical care inter-professional event on 8 May 2015, jointly organised by ANZICS & ACCCN.  
intensivecarenetwork.com
almost 6 years ago
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22

ECMO - Cardiohelp System - Intensive Care Network

Anaesthetist Dr Paul Forrest demonstrates the use of the CardioHelp System for ECMO. Presented at SMACCGold 2014.  
intensivecarenetwork.com
almost 6 years ago
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15

JICS Cast: Daniels - UK Sepsis Trust - Intensive Care Network

Olusanya & Day interview Ron Daniels, head of the UK Sepsis Trust. Daniels discusses the worldwide effort for better recognition & treatment of sepsis.  
intensivecarenetwork.com
almost 6 years ago
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16

ICU Post Mitral Valve Surgery - Intensive Care Network

Pierre Janin, an Intensivist from RNSH Sydney, discusses post mitral valve surgery management, highlighting the common issues and how to handle them.  
intensivecarenetwork.com
almost 6 years ago