Stream Bone marrow derived cell therapy in ischemic cardiomyopathy by BMJ talk medicine from desktop or your mobile device
almost 8 years ago
White Blood Cell Monitoring During Long-Term Clozapine Treatment: American Journal of Psychiatry: Vol 170, No 4
Late-onset agranulocytosis is rare during treatment with clozapine, especially in monotherapy. The authors describe a case of agranulocytosis that emerged after 19 years of continuous clozapine monotherapy. The discovery of the agranulocytosis was due to the lifelong white blood cell counts that are now required for clozapine treatment. Despite the fact that this requirement probably saved the life of this patient, this monitoring is not evidence-based because the incidence of agranulocytosis does not exceed that of conventional antipsychotic drugs, for which no such requirement exists. For mentally competent and adequately informed patients, the Netherlands Clozapine Collaboration Group now permits quarterly monitoring after the first 6 months of clozapine treatment.
almost 8 years ago
The innate immune system, which consists of the normal flora, physical barriers such as the skin, antibacterial proteins and phagocytic cells, is an important defence mechanism against infection. Many responses to ‘harm’ are detected by pattern recognition molecules such as […]
over 7 years ago
Stream Admission neutrophil–lymphocyte ratio predicts 90 day outcome after endovascular stroke therapy by BMJ talk medicine from desktop or your mobile device
over 7 years ago
Medical Microbiology begins with a review of the immune system, focusing on the body's response to invading microorganisms. Bacteria are then covered, first with a series of chapters presenting the general concepts of bacterial microbiology and then with chapters detailing the major bacterial pathogenes of humans. Similar sections cover virology, mycology, and parasitology. In each section, the introductory chapters stress the mechanisms of infection characteristic of that type of microorganism, thus providing the reader with a framework for understanding rather than memorizing the clinical behavior of the pathogens. The final section of the book Introduction to Infectious Diseases, is arranged by organ system and provides transition for clinical considerations.
over 7 years ago
Many may be familiar with aspergillosis as the infecting agent in acute cases where the patient is severely immunocompromised - but there is more to this fungus' repertoire. There are rare cases where the patient's immune system is overwhelmed by a large inhalation of spores e.g. after gardening, but these are insignificant in terms of total numbers effected. The following are far more common:- Aspergillus and other fungi are increasingly identified as the active agent in sinusitis - if you have cases that don't respond to antibiotics this is worth thinking about. Chronic pulmonary aspergillosis (CPA & aspergilloma) is an infection of immunocompetent people, causing respiratory difficulty, coughing and haemoptysis. The UK NHS has a specialist centre for these patients In Manchester (National Aspergillosis Centre (NAC)). NAC has particular expertise and extensive facilities for the diagnosis of CPA, ABPA, SAFS and use of systemic antifungal drugs. Allergic infection (Allergic Bronchopulmonary Aspergillosis - ABPA and chronic sinusitis) is thought to be heavily underdiagnosed and undertreated. ABPA is particularly common in Asthma, Cystic Fibrosis patients and those with bronchiectasis. There is estimated to be 25 000 cases in the UK alone. Many (50%) of the most severe asthma cases are sensitive to fungi (SAFS) - in particular Aspergillus. These tend to be the most unstable cases that don't respond to antibiotics and several studies have been published that show giving an antifungal helps reduce the use of steroids for these patients. Last but not least - Tuberculosis is on the rise in the UK and the rest of the world. It is estimated that 2% of cases progress to CPA and should be treated using an antifungal - this is usually not done until considerable time has passed and much damage has been done. In total it is estimated that many millions of people across the world suffer from aspergillus - ABPA - 5 million, Tb - 400 000 per year and Asthma (SAFS - 1 - 4 million cases in EU & US). Sinusitis cases may number many tens of millions worldwide. So - the next time you assume aspergillus infections and aspergillosis are rare and confined to those who are profoundly immunocompromised - think again! If you have a patient who has increasingly severe respiratory symptoms, doesn't respond to multiple courses of antibiotics then give aspergillus a thought. Browse around these articles for further information Aspergillus Website Treatment Section. NB For a broader look at the prevalence of fungal diseases worldwide the new charity Leading International Fungal Education (LIFE) website is worth looking at.
about 9 years ago
As more and more knowledge about our health is becoming evident, people everywhere are looking at new and innovative ways like Health Evangelism as a means of treatment. Getting a clean bill of health is a challenge for many people these days. For that reason many people are looking at different types of health care options that may stray a bit from the traditional but still give the patient needed relief from their physical problems. This is where new approaches have come in to help gain control of many of the medical issues that many people have to face. What is Health Evangelism? The expression ‘health evangelism’ is defined as an applying of the principles of healthful living in a way that includes physical laws that have been set forth by God to act in our lives. This is simply recognizing that God, as the provider of life, created us to function in a very specific way. Many of the physical health problems that we face are a direct result of going against those inborn laws that he set forth. Health Evangelism is a means of identifying those laws and not only using them within but passing them on to others in an evangelizing work. Benefits of Health Evangelism Your knowledge of the physical laws that he has set in motion have been instrumental in helping to improve a number of major health concerns of many people. For example, just coming to an understanding of your diet and how certain foods were designed to nourish your body can help to improve blood sugar health, cholesterol levels, cardiovascular conditioning, and your immune system among other things. Higher Spiritual Plane As you see how this understanding has had a major impact on the improvement of your health you will reach a point where, you will develop a personal relationship with your creator and the things he’s provided. Your care for your health and physical well-being will not be just taking care of yourself but you will come to view it as a part of your worship to your spiritual benefactor. By doing this, you will have reached a higher spiritual level that you may not have discovered otherwise. We have all been wonderfully made and our appreciation for our creation is a demonstration that we are part of something that extends far beyond our own personal world. Learning the details of Health Evangelism can open our eyes to many of the things unseen from the world around us. For more information, visit http://www.pambrarmd.com/contact.php.
over 8 years ago
When you think of the term 'bacteria', it immediately conjures up an image of a faceless, ruthless enemy-one that requires your poor body to maintain constant vigilance, fighting the good fight forever and always. And should you happen to lose the battle, well, the after effects are always messy. But what some people might not know is that bacteria are our silent saviours as well. These 'good' bacteria are known as probiotics, where 'pro' means 'for' and 'bios' is 'life'. The WHO defines probiotics as "live micro-organisms which, when administered in adequate amounts, confer a health bene?t on the host". Discovered by the Russian scientist Metchnikoff in the 20th century; simply put, probiotics are micro-organisms such as bacteria or yeast, which improve the health of an individual. Our bodies contain more than 500 different species of bacteria which serve to maintain our health by keeping harmful pathogens in check, supporting the immune system and helping in digestion and absorption of nutrients. From the very first breath you take, you are exposed to probiotics. How so? As an infant passes through it's mother's birth canal, it receives a good dose of healthy bacteria, which in turn serve to populate it's own gastro-intestinal tract. However, unfortunately, as we go through life, our exposure to overly processed foods, anti-bacterial products, sterilized and pasteurized food etc, might mean that in our zeal to have everything sanitary and hygienic, we might be depriving ourselves of the beneficial effects of such microorganisms. For any health care provider, the focus should not only be on eradicating disease but improving overall health as well. Here, probiotic containing foods and supplements play an important role as they not only combat diseases but also confer better health in general. Self dosing yourself with bacteria might sound a little bizarre at first-after all, we take antibiotics to fight bacteria. But let's not forget that long before probiotics became a viable medical option, our grandparents (and their parents before them) advocated the intake of yoghurt drinks (lassi). The fermented milk acts as an instant probiotic delivery system to the body! Although they are still being studied, probiotics may help several specific illnesses, studies show. They have proven useful in treating childhood diarrheas as well as antibiotic associated diarrhea. Clinical trial results are mixed, but several small studies suggest that certain probiotics may help maintain remission of ulcerative colitis and prevent relapse of Crohn’s disease and the recurrence of pouchitis (a complication of surgery during treatment of ulcerative colitis). They may also help to maintain a healthy urogenital system, preventing problems such as vaginitis and UTIs. Like all things, probiotics may have their disadvantages too. They are considered dangerous for people with impaired immune systems and one must take care to ensure that the correct strain of bacteria related to their required health benefit is present in such supplements. But when all is said and done and all the pros and cons of probiotics are weighed; stand back ladies and gentlemen, there's a new superhero in town, and what's more-it's here to stay!
over 8 years ago
In a series of studies, researchers identify a number of factors - such as breastfeeding - that may influence a baby's gut bacteria composition and their likelihood of allergies.
about 7 years ago
A novel approach to cancer immunotherapy - strategies designed to induce the immune system to attack cancer cells - may provide a new and cost-effective weapon against some of the most deadly...
about 7 years ago