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LiverDiseases

Category

715f5074e01e39e9012f5766ec26a3200a7bcfba25707655516104455
84
4407

Wilson's Disease: Definition, Symptoms & Pathophysiology

Excellent video covering the pathophysiology of Wilson's disease, as well as common signs and symptoms, complications, and treatments.  
youtube.com
over 5 years ago
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13
180

Liver Disease Part I

http://www.facebook.com/ArmandoHasudungan  
Nicole Chalmers
almost 8 years ago
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10
155

Alcoholic Liver Disease and Terlipressin use in Variceal bleeds

A presentation I gave to AAU team in our teaching. A brief basic overview of alcoholic liver disease and the use of Terlipressin in Variceal bleeds - the cochrane review is used for evidence base.  
Lara Gibbs
about 12 years ago
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9
202

Liver Cirrhosis (Causes II)

https://www.facebook.com/ArmandoHasud... Sorry this has to be two parts, I need a better computer, the movie making program is terrible... https://www.facebook.com/ArmandoHasud...  
Nicole Chalmers
almost 8 years ago
Preview
6
243

Liver Diseases Explained Clearly

Understand key differences between the main acute and chronic liver diseases with this clear explanation from Dr. Roger Seheult. Includes discussion of alcoh...  
YouTube
over 7 years ago
30080
4
207

Liver pathology 1

Video tutorial outlining the basic anatomy and physiology of the liver followed by a summary of acute and chronic liver disease, hepatic failure and cirrhosis.  
Podmedics
about 10 years ago
Preview
4
153

Liver Cirrhosis (Causes I)

Sorry this has to be two parts, I need a better computer, the movie making program is terrible... https://www.facebook.com/ArmandoHasudungan  
Nicole Chalmers
almost 8 years ago
Preview
3
106

Liver Cirrhosis

https://www.facebook.com/ArmandoHasudungan  
Nicole Chalmers
almost 8 years ago
Preview
3
137

Clinical Consequences of Liver Disease

Vitamins A, D, E and K are all stored in the liver, as is vitamin B12. Therefore, in liver damage, you can’t store as many of these as you would like to.   Portal circulation Note that there are no valves in the portal circulation. The portal supply is 70% of the blood that the liver receives. The other 30% is supplied by the hepatic artery.   The four main veins that contribute to the portal system are: Splenic vein Superior mesenteric  
almostadoctor.com - free medical student revision notes
over 7 years ago
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3
129

Alcoholic Hepatitis

This is a very common cause of liver injury. It is caused by excessive alcohol intake. Typically there will be steatosis of the liver. In this pathological change, fat globules begin to accumulate in the cytoplasm of liver cells. this can be pretty harmless, and as a result, is not very specific for predicting if the liver will develop cirrhosis.  
almostadoctor.com - free medical student revision notes
over 7 years ago
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3
101

Hepatitis B/ Chronic Hepatitis/Serum Hepatitis

• In the family Hepadnaviridae; common name: Hepadnavirus • Known as the smallest DNA virus • Double stranded, circular 42 nm DNA genome;Virion also called Dan…  
SlideShare
over 7 years ago
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2
40

Wilson's Disease

Inheritance: autosomal recessive Pathology:copper incorporation into caeruloplasmin in hepatocytes and and its excretion into bile is impaired so copper is deposited into organs (firstly liver, then basal ganglia) Clinical: - Presents in children with liver failure/jaundice - Presents in young adults with CNS signs e.g. ataxia, tremor, dysarthria  - Eyes: kayser fleischer rings (gold ring around iris)   
almostadoctor.com - free medical student revision notes
over 7 years ago
Preview
2
48

Liver Cirrhosis Causes II

More Anatomy Lessons : https://www.youtube.com/user/AnatomyProfStudent Anatomy video Anatomy vagin Anatomy penis Anatomy prof students Anatomy videos medical...  
YouTube
over 7 years ago
%3fr=0
2
138

A Modest Man

The registrar's face was taking on a testy look. So enduring was the silence our furtive glances had developed a nystagmic quality. “Galactosaemia” came her peremptory reply. Right on queue the disjointed chorus of ahs and head nods did little to hide our mental whiteboard of differentials being wiped clean. At the time conjugated bilirubinaemia in children only meant one thing: biliary atresia. A fair assumption; we were sitting in one of three specialist centres in the country equipped to treat these patients. Ironically the condition has become the unwieldy yardstick I now measure the incidence of paediatric disease. Biliary atresia is the most common surgical cause of neonatal jaundice with a reported incidence of 1 in 14-16ooo live births in the West. It is described as a progressive inflammatory obliteration of the extrahapatic bile duct. And Dr Charles West, the founder of Great Ormond Street Hospital, offers an eloquent description of the presenting triad of prolonged jaundice, pale acholic stools and dark yellow urine: ‘Case 18...It was born at full term, though small, apparently healthy. At 3 days however, it began to get yellow and at the end of 3 weeks was very yellow. Her motions at no time after the second day appeared natural on examination, but were white, like cream, and her urine was very high coloured.’ 1855 was the year of Dr West's hospital note. An almost universally fatal diagnosis and it would remain so for the next 100 years. The time's primordial classification of biliary atresia afforded children with the 'noncorrectable' type, a complete absence of patent extrahepatic bile duct, an unfortunate label; they were beyond saving. Having discovered the extent of disease at laparatomy, the surgeons would normally close the wound. The venerable Harvardian surgeon, Robert E. Gross saved an enigmatic observation: “In most instances death followed a downhill course…” K-A-S-A-I read the ward’s board. It was scrawled under half the children's names. I dismissed it as just another devilishly hard acronym to forget. The thought of an eponymous procedure had escaped me and in biliary atresia circles, it's the name everyone should know: Dr Morio Kasai. Originating from Aomori prefecture, Honshu, Japan, Dr Kasai graduated from the National Tohoku University School of Medicine in 1947. His ascension was rapid, having joined the 2nd department of Surgery as a general surgeon, he would assume the role of Assistant Professor in 1953. The department, under the tenure of Professor Shigetsugu Katsura, shared a healthy interest in research. 1955 was the landmark year. Katsura and Kasai operated on their first case: a 72 day old infant. Due to bleeding at the incised porta hepatis, Katsura is said to have 'placed' the duodenum over the site in order to staunch the flow. She made a spectacular postoperative recovery, the jaundice had faded and there was bile pigment in her stool. During the second case, Katsura elected to join the unopened duodenum to the porta hepatis. Sadly the patient's jaundice did not recover, but the post-mortem conducted by Kasai confirmed the development of a spontaneous internal biliary fistula connecting the internal hepatic ducts to the duodenum. Histological inspection of removed extrahepatic duct showed the existence of microscopic biliary channels, hundreds of microns in diameter. Kasai made a pivotal assertion: the transection of the fibrous cord of the obliterated duct must contain these channels before anastomosis with the jejunal limb Roux-en-Y loop. This would ensure communication between the porta hepatis and the intrahepatic biliary system. The operation, entitled hepatic portoenterostomy, was first performed as a planned procedure for the third case at Tohoku. Bile flow was restored and Kasai published the details of the new technique in the Japanese journal Shujutsu in 1959. However, news of this development did not dawn on the West until 1968 in the Journal of Pediatric Surgery. The success of the operation and its refined iterations were eventually recognized and adopted in the 1970s. The operation was and is not without its dangers. Cholangitis, portal hypertension, malnutrition and hepatopulmonary syndrome are the cardinal complications. While diagnosing and operating early (<8 weeks) are essential to the outcome, antibiotic prophylaxis and nutritional support are invaluable prognostic factors. Post operatively, the early clearance of jaundice (within 3 months) and absence of liver cirrhosis on biopsy, are promising signs. At UK centres the survival after a successful procedure is 80%. The concurrent development of liver transplantation boosts this percentage to 90%. Among children, biliary atresia is the commonest indication for transplantation; by five years post-Kasai, 45% will have undergone the procedure. On the 6th December 2008, Dr Kasai passed away. He was 86 years old and had been battling the complications of a stroke he suffered in 1999. His contemporaries and disciples paint a humble and colourful character. A keen skier and mountaineer, Dr Kasai lead the Tohoku University mountain-climbing team to the top of the Nyainquntanglha Mountains, the highest peaks of the Tibetan highlands. It was the first successful expedition of its kind in the world. He carried through this pioneering spirit into his professional life. Paediatric surgery was not a recognized specialty in Japan. By founding and chairing multiple associations including the Japanese Society of Pediatric Surgeons, Dr Kasai gave his specialty and biliary atresia, the attention it deserved. Despite numerous accolades of international acclaim for his contributions to paediatric surgery, Dr Kasai insisted his department refer to his operation as the hepatic portoenterostomy; the rest of the world paid its originator the respect of calling it the ‘Kasia’. Upon completion of their training, he would give each of his surgeons a hand-written form of the word ‘Soshin’ [simple mind], as he believed a modest surgeon was a good one. At 5 foot 2, Kasai cut a more diminutive figure one might expect for an Emeritus Professor and Hospital Director of a university hospital. During the course of his lifetime he had developed the procedure and lived to see its fruition. The Kasia remains the gold standard treatment for biliary atresia; it has been the shinning light for what Willis J. Potts called the darkest chapter in paediatric surgery. It earned Dr Kasai an affectionate but apt name among his peers, the small giant. References Miyano T. Morio Kasai, MD, 1922–2008. Pediatr Surg Int. 2009;25(4):307–308. Garcia A V, Cowles RA, Kato T, Hardy MA. Morio Kasai: a remarkable impact beyond the Kasai procedure. J Pediatr Surg. 2012;47(5):1023–1027. Mowat AP. Biliary atresia into the 21st century: A historical perspective. Hepatology. 1996;23(6):1693–1695. Ohi R. A history of the Kasai operation: Hepatic portoenterostomy for biliary atresia. World J Surg. 1988;12(6):871–874. Ohi R. Morio Kasai, MD 1922-2008. J Pediatr Surg. 2009;44(3):481–482. Lewis N, Millar A. Biliary atresia. Surg. 2007;25(7):291–294. This blog post is a reproduction of an article published in the Medical Student Newspaper, April 2014 issue.  
James Wong
over 7 years ago
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2
90

Amebic liver abscess - usmle imp points

Liver abscess is a pus-filled cyst in the liver. The liver is an organ in the digestive system that assists the digestive process and carries out many other ...  
youtube.com
about 6 years ago
8
1
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HCCU1 2007 | 51yo w/rcrrnt hep C after liver trans for HCC and cirrhotic liver dis

HCCUpdate.com – 51yo, recurrent hep C after liver transplantation for HCC, cirrhotic liver disease. Interviews conducted by Neil Love, MD. Produced by Research To Practice.  
Dr Neil Love
about 11 years ago