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15

Bioenergetics: The transformation of free energy in living systems

Visit us (http://www.khanacademy.org/science/healthcare-and-medicine) for health and medicine content or (http://www.khanacademy.org/test-prep/mcat) for MCAT...  
youtube.com
almost 7 years ago
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31

Why we need metabolism?

Visit us (http://www.khanacademy.org/science/healthcare-and-medicine) for health and medicine content or (http://www.khanacademy.org/test-prep/mcat) for MCAT...  
youtube.com
almost 7 years ago
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Why we need metabolism? - YouTube

Visit us (http://www.khanacademy.org/science/healthcare-and-medicine) for health and medicine content or (http://www.khanacademy.org/test-prep/mcat) for MCAT...  
youtube.com
almost 7 years ago
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3

Tissue specific metabolism and the metabolic states

Visit us (http://www.khanacademy.org/science/healthcare-and-medicine) for health and medicine content or (http://www.khanacademy.org/test-prep/mcat) for MCAT...  
youtube.com
almost 7 years ago
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Tissue specific metabolism and the metabolic states - YouTube

Visit us (http://www.khanacademy.org/science/healthcare-and-medicine) for health and medicine content or (http://www.khanacademy.org/test-prep/mcat) for MCAT...  
youtube.com
almost 7 years ago
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25

Understanding F-2,6-BP & Glycolysis (USMLE Step 1)

http://www.usmlesuccess.net A look at the formation of the allosteric activator of PFK-1 in glycolysis. This high-yield nugget is essential for the Step 1 ex...  
youtube.com
almost 7 years ago
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39

Food that helps & reduces iron absorption in the body

Prepare for USMLE,UK,CANADIAN,AUSTRALIAN, NURSING & OTHER MEDICAL BOARD examinations around the globe with us.Understand the basics, concepts and how to answ...  
youtube.com
almost 7 years ago
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Food that helps & reduces iron absorption in the body - YouTube

Prepare for USMLE,UK,CANADIAN,AUSTRALIAN, NURSING & OTHER MEDICAL BOARD examinations around the globe with us.Understand the basics, concepts and how to answ...  
youtube.com
almost 7 years ago
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17

Biology Help: Biology 123 Chapter 6 Cell Respiration--A Light Overview

Cell respiration, oxidative, glucose, ATP, oxygen, carbon dioxide, substrate, oxidation, reduction, glycolysis, krebs cycle, Citric Acid Cycle, NADH, FADH2, ...  
youtube.com
almost 7 years ago
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13

Mapping energy metabolism of growing nerve cells to better understand neuronal disorders

Scientists from Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS) in Japan have have discovered how nerve cells adjust to low energy environments during the brain's...  
medicalnewstoday.com
almost 7 years ago
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New views of enzyme structures offer insights into metabolism of cholesterol, other lipids

With the aid of X-ray crystallography, researchers at the University of Michigan have revealed the structures of two closely related enzymes that play essential roles in the body's ability to...  
medicalnewstoday.com
almost 7 years ago
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11

Obese females who are most unlikely to lose weight are most in need of losing it

In obese females, a close relationship may exist between their disinhibition (detrimental eating and behavioral characteristics) that limits successful weight loss, and impaired metabolism, new...  
medicalnewstoday.com
almost 7 years ago
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13

A new piece in the 'French paradox' puzzle -- cheese metabolism

Figuring out why the French have low cardiovascular disease rates despite a diet high in saturated fats has spurred research and many theories to account for this phenomenon known as the 'French...  
medicalnewstoday.com
almost 7 years ago
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A new piece in the 'French paradox' puzzle -- cheese metabolism

Figuring out why the French have low cardiovascular disease rates despite a diet high in saturated fats has spurred research and many theories to account for this phenomenon known as the 'French paradox.' Most explanations focus on wine and lifestyle, but a key role could belong to another French staple: cheese. The evidence, say scientists in ACS' Journal of Agricultural and Food Chemistry, is in cheese metabolism.  
eurekalert.org
almost 7 years ago
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BioMed Notes

Obesity in humans is associated with a region around FTO, a "fat mass and obesity-associated” gene on chromosome 16. Although this is the strongest genetic association, it accounts for only a 1-2% difference in Body Mass Index (BMI) and the mechanism was unknown. Here, the investigators looked at regulator proteins binding to variants DNA sequences within the FTO region, particularly those binding to sites with single nucleotide polymorphisms (SNPs), in 100 healthy Europeans -- 52 subjects were homozygous for 3 risk-variant SNPs (both alleles, all 3 loci) and the remaining 48 were homozygous for the non-risk variants. They found that the change of a T-to-C at one SNP within a risk allele of FTO prevented the binding of the repressor protein ARID5B. For want of this binding site, the repressor is lost. For want of this repressor, the expression of 2 linked genes doubles: IRX3, located about half a million base pairs (~0.5 Mbp) away, and IRX5, ~1 Mbp away. IRX3 repression made mice thinner by “increased energy dissipation without a change in physical activity or appetite”, i.e. not changing eating or exercise but rather elevating ‘metabolism’. The doubled expression of IRX3 led to a 5-fold reduction in mitochondrial thermogenesis and a 7-fold difference in brown/white adipose tissue development.  (Brown fat is brown because it holds more mitochondria, little furnaces that burn fat and produce heat.) The risk alleles are causative, and mediate through IRX3 and IRX5, because mimicking the repression of IRX3 or IRX5 in 8 carriers of the risk alleles, but not 10 carriers of the non-risk allele increased stimulated metabolism (Fig 3D, shown, left panel). And overexpression of IRX3 or IRX5 reduced stimulated metabolism in non-risk allele carriers (because their endogenous genes are repressed) but not in risk allele carriers (Fig 3D, right panel). Figure 3D. Oxygen consumption rate (OCR), basal and stimulated, in cells with risk or non-risk alleles. The take-home messages are that the causative SNP can be kilobases away from the genes that mediate the effect (not a huge surprise) and that small risks might develop from relatively big differences in particular developmental and cell biological pathways (reverse butterfly effect: not small-change-to-big-effect but big effect leads to small change (1-2% BMI)). N Engl J Med. 2015 Sep 3;373(10):895-907. “FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.” Claussnitzer M, Dankel SN, Kim KH, Quon G, Meuleman W, Haugen C, Glunk V, Sousa IS, Beaudry JL, Puviindran V, Abdennur NA, Liu J, Svensson PA, Hsu YH, Drucker DJ, Mellgren G, Hui CC, Hauner H, Kellis M  
biomednotes.blogspot.co.uk
over 6 years ago
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17

Muscle Metabolism | PhysiologyZone | Muscular Series

This is the 5th episode in the muscular series in which we will cover muscle metabolism and the ways in which muscles source their ATP. In summary we will co...  
youtube.com
over 6 years ago