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17

Artificial hand able to respond sensitively thanks to muscles made from smart metal wires

Engineers at Saarland University have taken a leaf out of nature's book by equipping an artificial hand with muscles made from shape-memory wire.  
medicalnewstoday.com
over 6 years ago
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Trauma program recoups investment by transforming lives, Australia

Enhanced surgery to reactivate the muscles in tetraplegics' hands and housing that allows people with disabilities to live independently are just two of the transformative benefits to come out...  
medicalnewstoday.com
over 6 years ago
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How does bench angle affect upper body muscle activation during bench press exercise?

Muscular activation during exercise is the key to developing muscle mass and strength and the bench press exercise is a popular and widely used method of building upper body strength.  
medicalnewstoday.com
over 6 years ago
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New approach to muscle regeneration restores function after traumatic injury without need for donor tissue

Loss of muscle volume is a common and often debilitating outcome of traumatic orthopedic injury, resulting in muscle weakness and suboptimal limb function.  
medicalnewstoday.com
over 6 years ago
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A strategy for stimulating heart muscle regeneration in infants, study finds

Surgery often is life-saving for many infants born with heart defects, but one thing that doctors cannot do yet is replace heart muscle that is scarred and dysfunctional.  
medicalnewstoday.com
over 6 years ago
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Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growth

Cell growth is orchestrated by changes in gene expression that respond to developmental and environmental cues. Among the signaling pathways that direct growth are enzymes of the protein kinase C (PKC) family, which are ubiquitous proteins belonging to three distinct subclasses: conventional PKCs, novel PKCs, and atypical PKCs. Functional overlap makes determining the physiological actions of different PKC isoforms difficult. We showed that two novel PKC isoforms, PKCδ and PKCε, redundantly govern stress-reactive and developmental heart growth by modulating the expression of cardiac genes central to stress-activated protein kinase and periostin signaling. Mice with combined postnatal cardiomyocyte-specific genetic ablation of PKCδ and germline deletion of PKCε (DCKO) had normally sized hearts, but their hearts had transcriptional changes typical of pathological hypertrophy. Cardiac hypertrophy and dysfunction induced by hemodynamic overloading were greater in DCKO mice than in mice with a single deletion of either PKCδ or PKCε. Furthermore, gene expression analysis of the hearts of DCKO mice revealed transcriptional derepression of the genes encoding the kinase ERK (extracellular signal–regulated kinase) and periostin. Mice with combined embryonic ablation of PKCδ and PKCε showed enhanced growth and cardiomyocyte hyperplasia that induced pathological ventricular stiffening and early lethality, phenotypes absent in mice with a single deletion of PKCδ or PKCε. Our results indicate that novel PKCs provide retrograde feedback inhibition of growth signaling pathways central to cardiac development and stress adaptation. These growth-suppressing effects of novel PKCs have implications for therapeutic inhibition of PKCs in cancer, heart, and other diseases.  
stke.sciencemag.org
over 6 years ago
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More than a stretch: Yoga's benefits may extend to the heart - Harvard Health Blog

Yoga is good for the muscles and the mind. New research suggests it may also be good for the heart.  
health.harvard.edu
over 6 years ago
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Selenide protects heart muscle in the wake of cardiac arrest

Damage to heart muscle from insufficient blood supply during cardiac arrest and reperfusion injury after blood flow is restored can be reduced by nearly 90 percent if selenide, a form of the essential nutrient selenium, is administered intravenously in the wake of the attack, according to a new preclinical study by Mark Roth, Ph.D., and colleagues at Fred Hutchinson Cancer Research Center.  
eurekalert.org
over 6 years ago
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Try this: Combo lunge also works arms and back in less time

Kim Lyons, the founder of Bionic Body in Hermosa Beach, says she got back into shape after the birth of her son using time-saving exercise combos that give you a cardio pump while also toning muscles. "More bang for your buck," as she puts it. The combo she shares with us this week actually does...  
latimes.com
over 6 years ago
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Critical Care

There is an increasing focus on intensive care unit-acquired weakness, its underlying mechanisms and therapeutic options. In this article we offer a commentary on the paper by Bloch and colleagues entitled 'MiR-181a: a potential biomarker of acute muscle wasting following cardiac surgery'. There is a need for biomarkers for intensive care unit-acquired weakness, not only in clinical practice but also in order to streamline future therapeutic trials. MicroRNAs are attractive biomarkers, and may have an important role in this disease. We highlight the significance of the authors’ finding of miR-181a, a novel plasma biomarker for the development of acute muscle wasting in post-operative cardiac surgery patients and discuss future research that is needed in this field following on from the study findings.  
ccforum.com
over 6 years ago
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Muscle Physiology Explained (Quick Review)

Download this and other presentations for FREE from Examville's Study Aids section. View thousands of videos and download study aids and tutorials at Examvil...  
youtube.com
over 6 years ago
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9

Psychological therapies for sickle cell disease and pain | Cochrane

Sickle cell disease is a group of blood disorders. It can cause anaemia, which if severe can reduce mobility. It may also allow small blood vessels to become blocked causing pain in muscle and bone and it can damage major organs such as the spleen, liver, kidneys, and lungs. People with sickle cell disease are more vulnerable to severe infections. Treatment is usually in response to symptoms and designed to ease pain. Psychological treatment to help people cope with sickle cell disease might complement current medical treatment. There are four types of treatment: patient education; cognitive therapy (to do with thoughts and feelings); behavioural therapy (to do with actions); psychodynamic psychotherapy (talking to relieve emotional pain). We searched for randomised or quasi-randomised controlled trials which compared psychological treatments to each other or to no treatment in sickle cell disease. We included seven studies in the review, of which five, with 260 people, had data we could enter into the review. One study showed that cognitive behaviour therapy reduced the affective part of pain (feelings about pain), but not the sensory part (pain intensity). Another study of this therapy had inconclusive results for coping strategies and showed no difference on how different groups used the health service. A study using cognitive behavioural therapy with teenagers and their families at home did not show any difference when compared with education about sickle cell disease. One education study did not show a reduction in depression. Furthermore, one study in patient education helped improve attitudes to healthcare workers and medication use in adolescents and young adults. The authors believe that some patient education seems relevant for children, adolescents and young adults, while methods to improve the ability to cope in both children and adults are important. Nonetheless, these results may not apply to across all ages, clinical severity, types of pain (acute or chronic) that people with sickle cell disease have, or which country they live in. More research needs to be done in this area.  
cochrane.org
over 6 years ago
Www.bmj
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Anatomy classes, but not as we know them

The University of Edinburgh’s Anatomical Museum hosted a hands-on workshop on 2 June that gave participants a chance to paint muscles, tendons, and blood vessels of the neck …  
feeds.bmj.com
over 6 years ago
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Neuromuscular Junction | PhysiologyZone | Muscular Series

In this 3rd episode we will concentrate on the neuromuscular junction and the events by which an action potential reaches and then passes into a muscle. So w...  
youtube.com
over 6 years ago
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Muscle Overview | PhysiologyZone | Muscular Series

Welcome to PhysiologyZone! We hope you enjoy learning physiology using our modular format. In this module we will cover the muscular system physiology over a...  
youtube.com
over 6 years ago
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Topical non-steroidal anti-inflammatory drugs for acute musculoskeletal pain in adults | Cochrane

Acute musculoskeletal pain describes conditions like a sprained ankle or a muscle pull. These usually get better over two or three weeks without treatment, but can be very painful while they last.  
cochrane.org
over 6 years ago
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Muscle Metabolism | PhysiologyZone | Muscular Series

This is the 5th episode in the muscular series in which we will cover muscle metabolism and the ways in which muscles source their ATP. In summary we will co...  
youtube.com
over 6 years ago