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SGEM#116: Paramedics’ Got a Squeeze Box – Remote Ischemic Conditioning

Guest Skeptics: Clay Odell. Clay is a paramedic and Executive Director of Upper Valley Ambulance, a regional EMS system covering nine communities in rural New Hampshire and Vermont. He’s been involved in EMS for over 30 years in a variety of roles including urban paramedic, flight paramedic, an emergency nurse, and Chief of the State EMS Office in New Hampshire. Clay is very interested in EBM for EMS and says he’s trying really hard to learn, but continues to procrastinate about actually taking a statistics course again.  
thesgem.com
over 6 years ago
Www.bmj
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PET after chemotherapy identifies Hodgkin’s lymphoma patients who can avoid radiotherapy

Positron emission tomography (PET) scanning immediately after chemotherapy for Hodgkin’s lymphoma can identify patients who are likely to have good survival without radiotherapy, a study reported in the New England Journal of Medicine has found.1  
feeds.bmj.com
over 6 years ago
Medullary%20cycling1
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Physiology, Medullary Cycling and Amonium Trapping: Acid Base Tutorial, University of Connecticut Health Center

After ammoniagenesis, ammonium is taken up into the medullary interstitium via a process called medullary recycling. It is then pumped back into the tubular fluid at the level of the collecting duct, where it undergoes what is called ammonium trapping after which it is excreted.  
fitsweb.uchc.edu
over 6 years ago
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Hospital practice explains variation in outcomes in extremely premature infants, US study finds

Much of the variation seen in outcomes among infants born at 22, 23, or 24 weeks of gestation can be explained by differences in hospitals’ practices on whether to initiate active treatment to save the lives of these extremely premature newborns, concludes a new study in the New England Journal of Medicine.1  
feeds.bmj.com
over 6 years ago
Www.bmj
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CPR before medical services arrive more than doubles survival after cardiac arrest

Giving cardiopulmonary resuscitation before emergency medical services arrive more than doubles the 30 day survival rate in people who have a cardiac arrest out of hospital, shows a Swedish study reported in the New England Journal of Medicine.1  
feeds.bmj.com
over 6 years ago
Www.bmj
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Drug combination that corrects deficient protein in cystic fibrosis improves lung function

A combination of two drugs used to correct levels of the transmembrane protein that is defective or deficient in cystic fibrosis significantly improves patients’ lung function, show the results of two randomised studies published in the New England Journal of Medicine.1  
feeds.bmj.com
over 6 years ago
Www.bmj
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Drug combination that corrects deficient protein in cystic fibrosis improves lung function

A combination of two drugs used to correct levels of the transmembrane protein that is defective or deficient in cystic fibrosis significantly improves patients’ lung function, show the results of two randomised studies published in the New England Journal of Medicine.1  
feeds.bmj.com
over 6 years ago
Www.bmj
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Removing more tissue around breast tumour reduces need for further surgery

Removing additional tissue around the cavity left after excising a tumour during partial mastectomy in women with early breast cancer halves the rate of positive margins that require further surgery, a randomised study reported in the New England Journal of Medicine has shown.1  
feeds.bmj.com
over 6 years ago
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Dear NEJM: We both know that conflicts of interest matter.

0 Introduction 0 Recently the New England Journal of Medicine launched a media campaign challenging the negative perception of industry conflicts of intere  
pulmcrit.org
over 6 years ago
Www.bmj
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Angioplasty with paclitaxel coated balloon reduces restenosis in peripheral artery disease

Percutaneous transluminal angioplasty using a paclitaxel coated balloon notably improves arterial patency at one year when compared with the same procedure using a standard uncoated balloon in patients with femoropopliteal artery disease, a study in the New England Journal of Medicine has shown.1  
feeds.bmj.com
over 6 years ago
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Medical Statistics and Medical Errors, Part I

The field of medical statistics is poorly understood by many doctors and by most patients. An article in the New England Journal of Medicine that surveyed over 100 articles published in reputable medical journals stated that over 50% of them used medical statistics incorrectly, and furthermore stated that this misuse invalidated the clinical conclusions of many of these articles. In this blog I will not discuss esoterica such as when to use a two-tailed t-test rather than a one-tailed test, or the uses and misuses of the Cox regression analysis. Instead I will try to point out fallacies in reasoning and statistics that should cause you to doubt a result quoted in the journal or in the newspapers.  
ghthomas.blogspot.co.uk
over 6 years ago